An immunohistochemistry for S-100 protein by biotin avidin system technique was
done to evaluate the existence and distribution pattern of S-100 protein positive cells in
various tumors of salivary gland.
The results obtained were as follows.
1) Positive immunostaining for S-100 protein was observed in myoepithelial cell, serous
acinar cell and nervous bundle in normal salivary gland.
2) Strong immunoreactivity for S-100 protein was shown in plemorphic adenoma, which
was localized not only in myoepithelial cord or sheets of epithelial portion but also in
chondrocytes, stellate cells of myxoid stroma and in squamous keratin pearl of
mesenchymal metaplastic foci.
3) The S-100 protein was demonstrated in the tumor cells of tubular adenoma, actinic
cell tumors and in epidermoid area of mucoepidermoid tumors.
4) Immunoreactivity for S-100 protein, however, was not found in the tumor cells of
adenoid cystic carcinoma and adenolymphoma except for stroma reticulum cells.
5) Intensity of positive reaction for S-100 protein varied from cell to cell: Some had
intense immunoreactivity, whreas others were only weakly positive or completely
negative, even in myoepithelial cell nest of the same pleomorphic adenoma.
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